From 24a3fbe99386ec2f5df6431eab0b44be2de37831 Mon Sep 17 00:00:00 2001 From: "M. Taylor Saotome-Westlake" Date: Sun, 16 Feb 2020 19:28:18 -0800 Subject: [PATCH] Human Diversity sprint session 3: standing variation and introgression --- content/drafts/book-review-human-diversity.md | 9 +++++---- 1 file changed, 5 insertions(+), 4 deletions(-) diff --git a/content/drafts/book-review-human-diversity.md b/content/drafts/book-review-human-diversity.md index 640039c..e24a146 100644 --- a/content/drafts/book-review-human-diversity.md +++ b/content/drafts/book-review-human-diversity.md @@ -4,7 +4,7 @@ Category: commentary Tags: review (book), race, sex differences Status: draft -[This is a pretty good book](https://www.twelvebooks.com/titles/charles-murray/human-diversity/9781538744000/) about things we know about some ways in which people are taxonically different from each other! Honestly, I feel like I already knew most of this stuff?—sex differences in particular are kind of _my bag_—but some of the details were new to me, and it's nice to have it all bundled together in a paper book with lots of citations that I can chase down later when I'm skeptical or want more details about a specific thing! The main text is littered with pleonastic constructions like "The first author was Thisand-Such" (when discussing the results of a multi-author paper) or "Details are given in the note[n]", which feel clunky to read, but are _so much better_ than the all-too-common alternative of authors _not_ "showing their work". +[This is a pretty good book](https://www.twelvebooks.com/titles/charles-murray/human-diversity/9781538744000/) about things we know about some ways in which people are taxonically different from each other! Honestly, I feel like I already knew most of this stuff?—sex differences in particular are kind of _my bag_—but many of the details were new to me, and it's nice to have it all bundled together in a paper book with lots of citations that I can chase down later when I'm skeptical or want more details about a specific thing! The main text is littered with pleonastic constructions like "The first author was Thisand-Such" (when discussing the results of a multi-author paper) or "Details are given in the note[n]", which feel clunky to read, but are _so much better_ than the all-too-common alternative of authors _not_ "showing their work". In the first part of this blog post, I'm going to summarize what I learned from (or was reminded of by) _Human Diversity_, but it would be kind of unhealthy for you to rely too much on tertiary blog-post summaries of secondary semi-grown-up-book literature summaries, so if these topics happen to strike your scientific curiosity, maybe you should skip this post and [go buy the source material](https://www.amazon.com/dp/B07Y82KNS1/)—or maybe even a grown-up textbook! @@ -32,11 +32,12 @@ Ask the computer to assume that an individual's ancestry came from _K_ fictive a These ancestry groupings _are_ a "construct" in the sense that the groupings aren't "ordained by God"—the algorithm can find _K_ groupings for your choice of _K_—but _where_ it [draws those category boundaries](https://www.lesswrong.com/posts/esRZaPXSHgWzyB2NL/where-to-draw-the-boundaries) is a function of the data. The construct is doing _cognitive work_, concisely summarizing statistical regularities in the dataset (which is _too large_ for humans to hold in their heads all at once): a map that reflects a territory. -Twentieth-century theorists like Fisher and Haldane and whatshisface-the-guinea-pig-guy had already figured out a lot about how evolution works (stuff like, a mutation that confers a fitness advantage of _s_ has a probability of about 2s of sweeping to fixation), but a lot of hypotheses about recent human evolution weren't easy to test, or formulate, until the genome was sequenced! +Twentieth-century theorists like Fisher and Haldane and whatshisface-the-guinea-pig-guy had already figured out a lot about how evolution works (stuff like, a mutation that confers a fitness advantage of _s_ has a probability of about 2s of sweeping to fixation), but a lot of hypotheses about recent human evolution weren't easy to test or even formulate until the genome was sequenced! -our migration out of Africa +You might think that there wasn't enough _time_ in the 2–5k generations since we came forth out of Africa for much human evolution to take place: a new mutation needs to confer an unusually large benefit to sweep to fixation that fast. But what if you didn't actually need any new mutations? Natural selection on polygenic traits can also act on "standing variation": variation _already_ present in the population that was mostly neutral in previous environments, but is fitness-relevant to new selection pressures. The rapid response to selective breeding observed in domesticated plants and animals mostly doesn't depend on new mutations. + +Another mechanism of recent human evolution is _introgression_: early humans interbred with our Neanderthal and Denisovan "cousins", giving our lineage the chance to "steal" all their good alleles! In contrast to new mutations, which usually die out even when they're beneficial (that 2s rule again), alleles "flowing" from another population keep getting reintroduced, giving them more chances to sweep! -Humans interbred with Neanderthals and Denisovans -- 2.17.1