From ffa9d00c8d23bff0bd69f4b1d5f3344fb2de609f Mon Sep 17 00:00:00 2001 From: "M. Taylor Saotome-Westlake" Date: Mon, 27 Apr 2020 23:21:51 -0700 Subject: [PATCH] soften the "shared environment doesn't" moral Thanks to my pre-readers for pushing back on this! --- content/drafts/book-review-human-diversity.md | 10 ++++++---- 1 file changed, 6 insertions(+), 4 deletions(-) diff --git a/content/drafts/book-review-human-diversity.md b/content/drafts/book-review-human-diversity.md index 9844564..11e6887 100644 --- a/content/drafts/book-review-human-diversity.md +++ b/content/drafts/book-review-human-diversity.md @@ -8,7 +8,7 @@ Status: draft Honestly, I feel like I already knew most of this stuff?—sex differences in particular are kind of _my bag_—but many of the details were new to me, and it's nice to have it all bundled together in a paper book with lots of citations that I can chase down later when I'm skeptical or want more details about a specific thing! The main text is littered with pleonastic constructions like "The first author was Jane Thisand-Such" (when discussing the results of a multi-author paper) or "Details are given in the note[n]", which feel clunky to read, but are _so much better_ than the all-too-common alternative of authors _not_ "showing their work". -In the first part of this blog post, I'm going to summarize what I learned from (or was reminded of by) _Human Diversity_, but it would be kind of unhealthy for you to rely too much on tertiary blog-post summaries of secondary semi-grown-up-book literature summaries, so if these topics happen to strike your scientific curiosity, you should probably skip this post and [go buy the source material](https://www.amazon.com/dp/B07Y82KNS1/)—or maybe even a grown-up textbook! +In the first part of this blog post, I'm going to summarize what I learned from (or thought about, or was reminded of by) _Human Diversity_, but it would be kind of unhealthy for you to rely too much on tertiary blog-post summaries of secondary semi-grown-up-book literature summaries, so if these topics happen to strike your scientific curiosity, you should probably skip this post and [go buy the source material](https://www.amazon.com/dp/B07Y82KNS1/)—or maybe even a grown-up textbook! The second part of this blog post is irrelevant. @@ -48,17 +48,19 @@ Sorry, "the Tibetans did it with ..." is sloppy phrasing on my part; what I actu The third part of the book is about genetic influences on class structure! Untangling the true causes of human variation is a really hard technical philosophy problem, but behavioral geneticists have at least gotten started with their simple _ACE_ model. It works like this: first, assume (that is, "pretend") that the genetic variation for a trait is _additive_ (if you have the appropriate SNP, you get more of the trait), rather than exhibiting _epistasis_ (where the effects of different loci interfere with each other) or Mendelian _dominance_ (where the presence of just one copy of an allele (of two) determines the phenotype, and it doesn't matter whether you heterozygously have a different allele as your second version of that gene). Then we pretend that we can partition the variance in phenotypes as the sum of the "additive" genetic variance _A_, plus the environmental variance "common" within a family _C_, plus "everything else" (including measurement "error" and the not-shared-within-families "environment") _E_. Briefly (albeit at the risk of being _cliché_): nature, nurture, and _noise_. -Then we can estimate the sizes of the _A_, _C_, and _E_ components by studying fraternal and identical twins. (If you hear people talking about "twin studies", this is what they mean—_not_ case studies of identical twins raised apart, which _are_ really cool but don't happen very often.) Both kinds of twins have the same family environment _C_ at the same time (parents, socioeconomic status, schools, _&c._), but identical twins are twice as genetically related to each other as fraternal twins, so the extent to which the identical twins are more similar is going to pretty much be because of their genes. "Pretty much" in the sense that while there are ways in which the assumptions of the model aren't quite true (assortative mating makes fraternal twins more similar in the ways their parents were _already_ similar before mating, identical twins might get treated more similarly by "the environment" on account of their appearance), the _quantitative_ effect of these deviations are probably pretty small! +Then we can estimate the sizes of the _A_, _C_, and _E_ components by studying fraternal and identical twins. (If you hear people talking about "twin studies", this is what they mean—_not_ case studies of identical twins raised apart, which _are_ really cool but don't happen very often.) Both kinds of twins have the same family environment _C_ at the same time (parents, socioeconomic status, schools, _&c._), but identical twins are twice as genetically related to each other as fraternal twins, so the extent to which the identical twins are more similar is going to pretty much be because of their genes. "Pretty much" in the sense that while there are ways in which the assumptions of the model aren't quite true (assortative mating makes fraternal twins more similar in the ways their parents were _already_ similar before mating, identical twins might get treated more similarly by "the environment" on account of their appearance), Murray assures us that the experts assure us that the _quantitative_ effect of these deviations are probably pretty small! -Anyway, it turns out that the effect of the shared environment _C_ is way smaller than most people intuitively expect—next to zero for personality and adult intelligence. The environment matters—just not the part of the environment shared by sibling in the same family. Just not the part of the environment we know how to control. Thus, a lot of economic and class stratification actually ends up being along genetic lines: the nepotism of family wealth can buy opportunities and second chances, but it doesn't actually live your life for you. +Anyway, it turns out that the effect of the shared environment _C_ for most outcomes is smaller than most people intuitively expect—actually close to zero for personality and adult intelligence specifically! Sometimes sloppy popularizers summarize this as "parenting doesn't matter" in full generality, but it depends on the trait or outcome you're measuring: for example, the shared environment component gets up to 25% for years-of-schooling ("educational attainment") and 36% for "basic interpersonal interactions." _Culture_ obviously exists, but for underlying psychological traits, the part of the environment that matters is mostly not shared by siblings in the same family—not the part of the environment we know how to control. Thus, a lot of economic and class stratification actually ends up being along genetic lines: the nepotism of family wealth can buy opportunities and second chances, but it doesn't actually live your life for you. It's important not to overinterpret the heritability results; there are a bunch of standard caveats that go here that everyone's treatment of the topic needs to include! Heritability is about the _variance_ in phenotypes that can be predicted by _variance_ in genes. This is _not_ the same concept as "controlled by genes." To see this, notice that the trait "number of heads" has a heritability of zero because the variance is zero: all living people have exactly one head. (Siamese twins are two people.) Heritability estimates are also necessarily bound to a particular population in a particular place and time, which can face constraints shaped solely by the environment. If you plant half of a batch of seeds in the shade and half in the sun, the variance in the heights of the resulting plants will be associated with variance in genes _within_ each group, but the difference _between_ the groups is solely determined by the sunniness of their environments. Likewise, in a Society with a cruel caste system under which children with red hair are denied internet access, part of the heritability of intellectual achievement is going to come from alleles that code for red hair. Even though (_ex hypothesi_) redheads have the same inherent intellectual potential as everyone else, the heritability computation can't see into worlds that are not our own, which might have vastly different gene–environment correlations. +(I speculate that heritability calculations being so Society-bound might help make sense of the "small role of the shared environment" results that many still balk at. If the population you're studying goes to public schools—or schools at all, as contrasted to [other ways of living and learning](https://en.wikipedia.org/wiki/Unschooling)—that could suppress a lot of the variance that might otherwise occur in families.) + Old-timey geneticists used to think that they would find small number of "genes for" something, but it turns out that we live in an omnigenetic, pleiotropic world where lots and lots of SNPs each exert a tiny effect on potentially lots and lots of things. I feel like this probably _shouldn't_ have been surprising (genes code for amino-acid sequences, variation in what proteins get made from those amino-acid sequences is going to affect high-level behaviors, but high-level behaviors involve _lots_ of proteins in a super-complicated unpredictable way), but I guess it was. Murray's penultimate chapter summarizes the state of a debate between a "Robert Plomin school" and an "Eric Turkheimer school" on the impact and import of polygenic scores, where we tally up all the SNPs someone has that are associated with a trait of interest. -The starry-eyed view epitomized by Plomin says that polygenic scores are _super great_ and everyone _and [her](/2020/Apr/the-reverse-murray-rule/) dog_ should be excited about them: they're causal in only one direction (the trait can't cause the score) and they let us assess risks in individuals before they happen. Clinical psychology will enter a new era of "positive genomics", where we understand how to work with the underlying dimensions along which people vary (including positively), rather than focusing on treated "diagnoses" that people allegedly "have". +The starry-eyed view epitomized by Plomin says that polygenic scores are _super great_ and everyone _and [her](/2020/Apr/the-reverse-murray-rule/) dog_ should be excited about them: they're causal in only one direction (the trait can't cause the score) and they let us assess risks in individuals before they happen. Clinical psychology will enter a new era of "positive genomics", where we understand how to work with the underlying dimensions along which people vary (including positively), rather than focusing on treating "diagnoses" that people allegedly "have". The curmudgeonly view epitomized by Turkheimer says that Science is about understanding the _causal structure_ of phenomena, and that polygenic scores don't fucking tell us anything. [Marital status is heritable _in the same way_ that intelligence is heritable](http://www.geneticshumanagency.org/gha/the-ubiquity-problem-for-group-differences-in-behavior/), not because there are "divorce genes" in any meaningful biological sense, but because of a "universal, nonspecific genetic pull on everything": on average, people with more similar genes will make more similar proteins from those similar genes, and therefore end up with more similar phenotypes that interact with the environment in a more similar way, and _eventually_ (the causality flowing "upwards" through many hierarchical levels of organization) this shows up in the divorce statistics of a particular Society in a particular place and time. But this is opaque and banal; the real work of Science is in figuring out what all the particular gene variations actually _do_. -- 2.17.1