-> CYP21 is on chromosome 6 and encodes an enzyme normally present in the adrenal gland called 21-hydroxylase (21-OH). Individuals with CAH due to 21-OH defi ciency are unable to produce enough cortisol to suppress the release of adrenocorticotropic hormone (ACTH). This results in an accumulation of products that normally become cortisol, which in turn results in increased production of androgen from the adrenal gland. This excess androgen has many of the same effects as testosterone produced by the testes in males
+> CYP21 is on chromosome 6 and encodes an enzyme normally present in the adrenal gland called 21-hydroxylase (21-OH). Individuals with CAH due to 21-OH deficiency are unable to produce enough cortisol to suppress the release of adrenocorticotropic hormone (ACTH). This results in an accumulation of products that normally become cortisol, which in turn results in increased production of androgen from the adrenal gland. This excess androgen has many of the same effects as testosterone produced by the testes in males