In a miracle of science, someone made the observations to notice that human females have higher levels of [(8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol](https://en.wikipedia.org/wiki/Estradiol) than human males. In a glorious exhibition of mad science, someone did the experiments to notice that artificially synthesizing that ...-iol (or collecting it from [pregnant horses' urine](https://www.fundforanimals.org/duchess-sanctuary/about-the-duchess-sanctuary/pregnant-mare-urine.html)) and administering it to males successfully pushes some aspects of their phenotype in the female direction: [breast growth and fat redistribution and agreeableness—at the cost of increased risk of venous thromboembolism and osteoporosis](https://srconstantin.github.io/2016/10/06/cross-sex-hormone-therapy.html).
In a miracle of science, someone made the observations to notice that human females have higher levels of [(8R,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol](https://en.wikipedia.org/wiki/Estradiol) than human males. In a glorious exhibition of mad science, someone did the experiments to notice that artificially synthesizing that ...-iol (or collecting it from [pregnant horses' urine](https://www.fundforanimals.org/duchess-sanctuary/about-the-duchess-sanctuary/pregnant-mare-urine.html)) and administering it to males successfully pushes some aspects of their phenotype in the female direction: [breast growth and fat redistribution and agreeableness—at the cost of increased risk of venous thromboembolism and osteoporosis](https://srconstantin.github.io/2016/10/06/cross-sex-hormone-therapy.html).